Xie Xin Tang Wan was created by the great ancient Chinese doctor Zhang Zhongjing about 1800 years ago to treat the "Pi syndrome" (痞症) marked by the focal distention or fullness in the stomach, along with various stomach discomforts. Such an array of signs is a display of coincident chills and heat. In the term of traditional Chinese medicine (TCM), the Pi syndrome is considered as a disharmony between the stomach and the spleen that results in the disturbance in the flow of the Qi energy both upwards and downwards in the stomach.

Many clinical studies have been conducted in China to relate the TCM application of Xie Xin Tang Wan to the gastrointestinal health in the modern biomedical terms. Studies suggested that it may support the content of gastric mucin and the mucoid lining of the stomach.